E346: $7 Billion CIO: Why the Endowment Model is Changing

Highlights:

• Why the most important skill for investors isn’t modeling—it’s building relationships with teams and managers
• How AI is reshaping portfolio management and why human judgment remains critical
• Playing offense and defense in a portfolio: spotting dislocations and leaning into opportunities
• Lessons from the endowment model: what still works, what needs evolution, and why illiquidity premiums aren’t guaranteed
• Strategies for accessing top-tier venture managers without decades of reputational capital
• The advantages of Spider’s single portfolio model across multiple clients and the “razor” it creates for disciplined investing
• Practical advice for career longevity: loving your work and balancing networking with building something meaningful

Guest bio:

Karen Welch is Chief Investment Officer at Spider Management Company, overseeing approximately $7 billion for the University of Richmond and affiliated nonprofit partners. Previously, she spent nearly a decade at Stanford’s endowment, where she honed her approach to portfolio construction, manager selection, and long-term investing. Known for her focus on relationships, strategic thinking, and disciplined portfolio management, Karen combines decades of endowment experience with a modern approach to private and public markets.

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Sponsor:

AlphaSense is the AI-powered market intelligence platform trusted by 85% of the S&P 100, helping investment professionals make faster, more confident, data-driven decisions. Built for hedge funds, asset allocators, private venture capital firms, and investment bankers, AlphaSense uses advanced AI and powerful search across premium proprietary content to surface the insights that matter most—before the market moves. Elevate your research and stay ahead of the competition. Visit https://www.alpha-sense.com/howiinvest/ to learn more.

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X/Twitter: @dweisburd LinkedIn: https://www.linkedin.com/in/dweisburd/ Weisburd Capital: https://www.weisburdcapital.com/

Stay Connected with Karen Welch:

LinkedIn:https://www.linkedin.com/in/karen-horn-welch/

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Disclaimer:

This podcast is for informational purposes only and does not constitute investment, financial, legal, or tax advice. Nothing in this episode should be interpreted as an offer to buy or sell any securities or to participate in any investment strategy. All opinions expressed by the host and guests are their own and do not represent the views of Weisburd Capital. Participants may hold positions or have financial interests in the companies, funds, or investments discussed. Any references to specific investments are for illustrative purposes only. Investing involves risk, including the potential loss of capital. Past performance is not indicative of future results, and any forward-looking statements are subject to risks and uncertainties. Any third-party data or opinions have not been independently verified. Listeners should conduct their own research and consult their own advisors before making any investment decisions.